Acoustic Cavitation as an Enhancing Mechanism of Low-Frequency Sonophoresis for Transdermal Drug Delivery
نویسندگان
چکیده
منابع مشابه
Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac
The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...
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IMPORTANCE OF THE FIELD Transdermal delivery of macromolecules provides an attractive alternative route of drug administration when compared to oral delivery and hypodermic injection because of its ability to bypass the harsh gastrointestinal tract and deliver therapeutics non-invasively. However, the barrier properties of the skin only allow small, hydrophobic permeants to traverse the skin pa...
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The research described in this thesis represents a significant advancement in the current mechanistic understanding of low-frequency ultrasound-mediated transdermal drug delivery. Specifically, while prior research has focused on a more general understanding of the mechanisms associated with low-frequency sonophoresis (LFS), this thesis directly investigates the mechanisms associated with pheno...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2009
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.32.916